Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
نویسندگان
چکیده
The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.
منابع مشابه
CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1.
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ورودعنوان ژورنال:
- Journal of virology
دوره 72 2 شماره
صفحات -
تاریخ انتشار 1998